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NASA recently ended a manned mission to the International Space Station (ISS) a month early, citing a medical issue with one of the astronauts. The space agency just revealed that the impacted astronaut was Mike Fincke. This was the first medical evacuation in the history of the ISS.
Real game engines use this pattern (or its 3D cousin, the Octree) for broad-phase collision detection: the quadtree quickly identifies candidate pairs, and a more expensive narrow-phase check tests the actual geometry.